MovDisordV3, Main, Exploration, bibRecord, 000772

Specific splice variants are associated with Parkinson’s disease

Identifieur interne : 000772 ( Main/Exploration ); précédent : 000771; suivant : 000773

Specific splice variants are associated with Parkinson’s disease

Auteurs : Jose A. Santiago [États-Unis] ; Clemens R. Scherzer [États-Unis] ; Harvard Biomarker Study [États-Unis] ; Judith A. Potashkin [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.

RBID : PMC:3812386

English descriptors

KwdEn :
- Aged, Biological Markers (blood), Female, Humans, Male, Middle Aged, Parkinson Disease (blood), Parkinson Disease (diagnosis), Protein Isoforms (blood).
MESH :
- chemical , blood : Biological Markers, Protein Isoforms.
- blood : Parkinson Disease.
- diagnosis : Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged.

Abstract

Background

Diagnosis of Parkinson’s disease (PD) currently relies on assessment of motor symptoms. Recently, sensitive, specific and readily available splice variant-specific biomarkers were identified in peripheral blood from participants in the Diagnostic and Prognostic Biomarkers in Parkinson Disease study.

Methods

Here we test for an association between candidate splice variant biomarkers and PD in blood of an independent population of cases and controls nested in the Harvard NeuroDiscovery Center Biomarker Study.

Results

Expression of seven out of thirteen candidate biomarkers was dysregulated in whole cellular blood of patients with PD.

Conclusions

These results support the view that differential expression of a subset of splice variant markers in blood is associated with PD. Further evaluation in untreated, de novo patients and at-risk subjects is warranted.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812386

DOI: 10.1002/mds.25635
PubMed: 24108702
PubMed Central: 3812386

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Diagnosis of Parkinson’s disease (PD) currently relies on assessment of motor symptoms. Recently, sensitive, specific and readily available splice variant-specific biomarkers were identified in peripheral blood from participants in the Diagnostic and Prognostic Biomarkers in Parkinson Disease study.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Here we test for an association between candidate splice variant biomarkers and PD in blood of an independent population of cases and controls nested in the Harvard NeuroDiscovery Center Biomarker Study.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Expression of seven out of thirteen candidate biomarkers was dysregulated in whole cellular blood of patients with PD.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">These results support the view that differential expression of a subset of splice variant markers in blood is associated with PD. Further evaluation in untreated, <italic>de novo</italic>
 patients and at-risk subjects is warranted.</p>
</sec>
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Movement Disorders (revue)

Specific splice variants are associated with Parkinson’s disease

Specific splice variants are associated with Parkinson’s disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki

	Movement Disorders (revue)
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